|“||The Raiders only accept the meanest and toughest SOBs around. You have to be bloodthirsty, violent, extreme.||”|
During the spring of 2141, four groups left Vault 15 to brave the Wasteland. In the winter of the same year, three of these groups became roving gangs of raiders: the Jackals, the Vipers, and the Khans. The Khans were founded and lead by the father of Garl Death-Hand (known as "The Death-Hand"), making regularly pillage raids, especially on Shady Sands, a community created by the last group of Vault 15.在2161年之前的某個時刻, Garl Death-Hand 殺了他的父親 成為可汗幫的頭目。在那之後, 可汗在沙城东南设立了据点，周围环绕着一些次要匪徒势力。
He continued the work of his father, continuing pillage against those who had the misfortune to spend too near their camp and on Shady Sands. After a hard day pillaging, they sometimes go to Junktown to relax after and trade their loot with the Hub, mostly for water and ammunition, but sometimes for weapons. 2161年，當時的可汗头目盖尔，在放逐者来营救被匪徒绑架的坦蒂时所杀。放逐者还杀掉了很多盖尔的同伴，除了一个叫做大流士的年轻人。Darion. 尽管可汗帮摆出一副吓人姿态，伊恩却把他们总结的相当透彻：一群“微不足道”的匪徒帮派罢了。
在加州的可汗幫近乎被根除之際， Papa Khan率領殘存的成員前往莫哈維成立大汗幫。After being driven out of the northern Mojave by Mr. House and the local tribes allied with him, the Great Khans settled at Bitter Springs and soon took to raiding the NCR settlers, whom they saw as intruders. After NCR began developing a military presence in the Mojave Wasteland, the Khans began raiding NCR outposts, as well. After so many disputes between the two factions, the NCR began systematically tracking the Khan raiding parties back to their base(s) of operation. NCR soldiers (including 1st Recon snipers) were ordered to seize the town of Bitter Springs, believing it to be a raiding camp and not the Khans' home. The survivors of the attack were driven back to Red Rock Canyon, a place with hardly any resources for survival.
After the massacre at Bitter Springs, the Followers of the Apocalypse offered their services for medical aid and support once the Great Khans reached Red Rock Canyon. They also taught the Great Khans how to make their own chems as a way of survival, but the Khans used this knowledge to make addictive chems instead of medicinal ones, leading to a successful trading business with the Fiends.
To this day, the Great Khan leader, Papa Khan, blames their situation on the NCR. However, he seems to be the only Great Khan higher-up that keeps an ongoing grudge against the NCR, and won't even consider the possibility that the massacre at Bitter Springs happened due to a communication mishap. Because of this, in 2281 he is deliberating on whether the Great Khans should ally themselves with Caesar's Legion, the NCR's main adversary in the Mojave Wasteland.
- 幫派名字起源於蒙古的首領尊稱:可汗，主要是 成吉思汗。