You can pick Evan King's lock with-out a karma penalty.
After the quest Blood Ties, King will leave his post and walk around and the residents will come out of their houses and walk around.
When you go back to Arefu and tell them to donate blood packs, Evan King will tell you to go back to Meresti and tell The Family they have a deal. However, you will not be able to tell The Family this.
Often a robot or some other wasteland creature will spawn in the center of the town.